Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,5R)-1-([4-[(2,4-dichlorobenzyl)oxy]phenyl]sulfonyl)-N,5-dihydroxy-3,3-dimethylpiperidine-2-carboxamide | - |
Homo sapiens | |
2-[4-(benzyloxy)phenyl]-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]quinoline-4-carboxylate | the inhibitor is unable to discriminate between ADAMTS-5 and ADAMTS-4 | Homo sapiens | |
2-[4-(benzyloxy)phenyl]-2,3-dihydro-N-hydroxy-1-oxo-1Hpyrrolo[3,4-c]quinoline-4-carboxamide | - |
Homo sapiens | |
2-[4-(benzyloxy)phenyl]-3-oxoisoindoline-4-carboxylic acid | does not inhibit ADAMTS-4 | Homo sapiens | |
2-[4-(benzyloxy)phenyl]-N-hydroxy-3-oxoisoindoline-4-carboxamide | does not inhibit ADAMTS-4 | Homo sapiens | |
additional information | design of ADAMTS-5 inhibitors | Homo sapiens | |
N2-(biphenyl-4-ylcarbonyl)-N-(2-phenylpropan-2-yl)-L-alpha-glutamine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan-interglobular domain + H2O | cleavage site Glu373-Ala374 in aggrecaninterglobular domain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS-5 | - |
Homo sapiens |
aggrecanase-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC25-value: 0.0025 mM, 37°C, pH and temperature not specified in the publication, plateau inhibition at about 50% | Homo sapiens | 2-[4-(benzyloxy)phenyl]-N-hydroxy-3-oxoisoindoline-4-carboxamide | |
additional information | - |
IC25-value: 0.0075 mM, 37°C, pH and temperature not specified in the publication, plateau inhibition at about 50% | Homo sapiens | 2-[4-(benzyloxy)phenyl]-3-oxoisoindoline-4-carboxylic acid | |
0.0000014 | - |
37°C, pH and temperature not specified in the publication | Homo sapiens | (2R,5R)-1-([4-[(2,4-dichlorobenzyl)oxy]phenyl]sulfonyl)-N,5-dihydroxy-3,3-dimethylpiperidine-2-carboxamide | |
0.00095 | - |
37°C, pH and temperature not specified in the publication | Homo sapiens | 2-[4-(benzyloxy)phenyl]-2,3-dihydro-N-hydroxy-1-oxo-1Hpyrrolo[3,4-c]quinoline-4-carboxamide | |
0.0011 | - |
37°C, pH and temperature not specified in the publication | Homo sapiens | N2-(biphenyl-4-ylcarbonyl)-N-(2-phenylpropan-2-yl)-L-alpha-glutamine | |
0.012 | - |
37°C, pH and temperature not specified in the publication | Homo sapiens | 2-[4-(benzyloxy)phenyl]-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]quinoline-4-carboxylate |