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Literature summary for 3.4.24.B12 extracted from
- ADAMTS-5: the story so far (2008), Eur. Cell Mater., 15, 11-26.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Mus musculus | |
| interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Homo sapiens | |
| interleukin-1alpha | increased transcription in the presence of interleukin-1alpha | Bos taurus | |
| interleukin-1beta | increased transcription in the presence of interleukin-1beta | Bos taurus | |
| oncostatin M | increased transcription in the presence of interleukin-1alpha | Homo sapiens | |
| retinoate | increased transcription in the presence of retinoate | Mus musculus |  |
| tissue necrosis factor alpha | increased transcription in the presence of tissue necrosis factor alpha | Bos taurus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO cells | Mus musculus |
| expressed in HTB-94 human chondrosarcoma cell line | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha2-Macroglobulin | - |
Bos taurus | |
| alpha2-Macroglobulin | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Mus musculus | |
| additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Bos taurus | |
| additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Homo sapiens | |
| additional information | TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 | Mus musculus | |
| TIMP-3 | potent inhibitor | Bos taurus | |
| TIMP-3 | potent inhibitor | Homo sapiens | |
| TIMP-3 | potent inhibitor | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | - |
Mus musculus | - |
| cartilage | - |
Homo sapiens | - |
| cartilage | - |
Bos taurus | - |
| chondrocyte | - |
Mus musculus | - |
| chondrocyte | - |
Homo sapiens | - |
| chondrocyte | - |
Bos taurus | - |
| mesenchymal stem cell | - |
Homo sapiens | - |
| synovial fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | - |
Mus musculus | ? | - |
? | |
| aggrecan + H2O | - |
Homo sapiens | ? | - |
? | |
| aggrecan + H2O | - |
Bos taurus | ? | - |
? | |
| additional information | deglycosylated aggrecan is a poor substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Mus musculus |
| a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Homo sapiens |
| a disintegrin and metalloproteinase with thrombospondin motifs-5 | - |
Bos taurus |
| ADAMTS-5 | - |
Mus musculus |
| ADAMTS-5 | - |
Homo sapiens |
| ADAMTS-5 | - |
Bos taurus |
| aggrecanase-2 | - |
Mus musculus |
| aggrecanase-2 | - |
Homo sapiens |
| aggrecanase-2 | - |
Bos taurus |
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