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Literature summary for 3.4.24.B11 extracted from

  • Mead, T.J.; Bhutada, S.; Foulcer, S.J.; Peruzzi, N.; Nelson, C.M.; Seifert, D.E.; Larkin, J.; Tran-Lundmark, K.; Filmus, J.; Apte, S.S.
    Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development (2024), Matrix Biol., 131, 1-16.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
versican + H2O Mus musculus versican proteolysis in cardiac jelly at the canonical Glu441-Ala442 site is cooperatively mediated by ADAMTS1 and ADAMTS5 and required for proper ventricular cardiomyogenesis ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P97857
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
versican + H2O versican proteolysis in cardiac jelly at the canonical Glu441-Ala442 site is cooperatively mediated by ADAMTS1 and ADAMTS5 and required for proper ventricular cardiomyogenesis Mus musculus ?
-
 ?
versican + H2O
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 Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
ADAMTS1
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 Mus musculus

General Information

General Information Comment Organism
malfunction combined inactivation of ADAMTS1 and ADAMTS5 prior to 12.5 days of gestation leads to dramatic accumulation of versican-rich cardiac jelly and inhibits formation of compact and trabecular myocardium Mus musculus
physiological function ADAMTS1 is a matrix-degrading metalloproteases. Versican proteolysis in cardiac jelly at the canonical Glu441-Ala442 site is cooperatively mediated by ADAMTS1 and ADAMTS5 and required for proper ventricular cardiomyogenesis Mus musculus