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Literature summary for 3.4.24.B11 extracted from

  • Minns, A.F.; Qi, Y.; Yamamoto, K.; Lee, K.; Ahnstroem, J.; Santamaria, S.
    The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity (2023), J. Biol. Chem., 299, 103048.
    View publication on PubMed
Search for more literature for 3.4.24.B11

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0135
-
 fluorescein-5(6)-carbonyl-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys 37°C, pH 7.45, wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Homo sapiens
-
 ?
-
 ?
versican + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UHI8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Homo sapiens ?
-
 ?
biglycan + H2O biglycan is a small leucine-rich proteoglycan Homo sapiens ?
-
 ?
fluorescein-5(6)-carbonyl-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys + H2O
-
 Homo sapiens ?
-
 ?
versican + H2O
-
 Homo sapiens ?
-
 ?
versican + H2O ADAMTS1 versicanase activity is approximately 1000fold lower than ADAMTS5 and 50fold lower than ADAMTS4 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS1
-
 Homo sapiens
disintegrin-like and metalloproteinase with thrombospondin type 1 motifs
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.054
-
 fluorescein-5(6)-carbonyl-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys 37°C, pH 7.45, wild-type enzyme Homo sapiens

General Information

General Information Comment Organism
additional information spacer and cysteine-rich domains as major determinants of ADAMTS1 versicanase activity. These C-terminal domains are involved in the proteolysis of aggrecan as well as biglycan, a small leucine-rich proteoglycan Homo sapiens
physiological function ADAMTS1 is involved in fertilization, cancer, cardiovascular development, and thoracic aneurysms Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.4
-
 versican 37°C, pH 7.45, wild-type enzyme Homo sapiens
42
-
 fluorescein-5(6)-carbonyl-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys 37°C, pH 7.45, wild-type enzyme Homo sapiens