Literature summary for 3.4.24.B11 extracted from

Gerhardt, S.; Hassall, G.; Hawtin, P.; McCall, E.; Flavell, L.; Minshull, C.; Hargreaves, D.; Ting, A.; Pauptit, R.A.; Parker, A.E.; Abbott, W.M.
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains (2007), J. Mol. Biol., 373, 891-902.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf21 insect cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with marimastat, sitting drop vapour diffusion method with 0.2-0.6 M sodium acetate, 0.05 M cadmium sulfate, 0.1 M HEPES (pH 7.0), and 12-22% glycerol	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
marimastat	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	contains a Ca2+-binding site	Homo sapiens
Zn2+	zinc metalloproteinase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UHI8	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA Superflow column chromatography, Ni-NTA resin column chromatography, and Superdex 75 gel filtration	Homo sapiens

Synonyms

Synonyms	Comment	Organism
a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs-1	-	Homo sapiens
ADAMTS-1	-	Homo sapiens

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Release 2023.1 (January 2023)