Literature summary for 3.4.24.B11 extracted from

Rodriguez-Manzaneque, J.C.; Milchanowski, A.B.; Dufour, E.K.; Leduc, R.; Iruela-Arispe, M.L.
Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms (2000), J. Biol. Chem., 275, 33471-33479.

Search for more literature for 3.4.24.B11

Cloned(Commentary)

Cloned (Comment)	Organism
expression as Myc-His-tagged wild-type and truncated mutant in 293T cell line	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation	?	-	?
proteins + H2O	Homo sapiens	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	secreted pro-METH-1 is processed in 2 consecutive steps to release a p87 and a p65 active form, cleavage by furin results in only the p87 fragment, the p87 form lacks the N-terminal prodomain, and p65 results from an additional processing event in the C-terminus requiring p87 which can be catalyzed by matrix metalloproteases 2,8, and 15	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
recombinant Myc-His-tagged enzyme from cell line 293T	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation	Homo sapiens	?	-	?
proteins + H2O	-	Homo sapiens	peptides	-	?

Synonyms

Synonyms	Comment	Organism
M12.222	Merops-ID	Homo sapiens
METH-1	-	Homo sapiens

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Release 2023.1 (January 2023)