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Literature summary for 3.4.24.B11 extracted from
- Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms (2000), J. Biol. Chem., 275, 33471-33479.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression as Myc-His-tagged wild-type and truncated mutant in 293T cell line | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation | ? | - |
? | |
| proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | secreted pro-METH-1 is processed in 2 consecutive steps to release a p87 and a p65 active form, cleavage by furin results in only the p87 fragment, the p87 form lacks the N-terminal prodomain, and p65 results from an additional processing event in the C-terminus requiring p87 which can be catalyzed by matrix metalloproteases 2,8, and 15 | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant Myc-His-tagged enzyme from cell line 293T | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation | Homo sapiens | ? | - |
? | |
| proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M12.222 | Merops-ID | Homo sapiens |
| METH-1 | - |
Homo sapiens |
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