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Literature summary for 3.4.24.B11 extracted from

  • Rodriguez-Manzaneque, J.C.; Westling, J.; Thai, S.N.; Luque, A.; Knauper, V.; Murphy, G.; Sandy, J.D.; Iruela-Arispe, M.L.
    ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors (2002), Biochem. Biophys. Res. Commun., 293, 501-508.
    View publication on PubMed
Search for more literature for 3.4.24.B11

Protein Variants

Protein Variants Comment Organism
E385A point mutation in the zinc binding domain results in an inactive mutant enzyme form Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline complete inhibition Homo sapiens
doxycycline partial inhibition Homo sapiens
EDTA complete inhibition Homo sapiens
heparin
-
 Homo sapiens
matrix metalloprotease inhibitor BB94
-
 Homo sapiens
matrix metalloprotease inhibitor I partial inhibition Homo sapiens
matrix metalloprotease inhibitor TIMP2 slight inhibition Homo sapiens
matrix metalloprotease inhibitor TIMP3 slight inhibition Homo sapiens
additional information no inhibition by minocycline, and matrix metalloprotease inhibitors TIMP1 and TIMP4 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-binding domain is essential for catalytic activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Homo sapiens
-
 ?
-
 ?
proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of prodomain by furin at furin-cleavage site RKKR Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Homo sapiens ?
-
 ?
additional information no activity with pro-collagen type I and III, collagen types I, II, IV, V, VIII and XVIII, fibronectin, laminin, vibronectin, and thrombospondin 1 Homo sapiens ?
-
 ?
peptide fragments of aggrecan + H2O peptide sequences contain the cleavage site of aggrecan at E373-A374 Homo sapiens ?
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?
versican + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Homo sapiens
ADAMTS1
-
 Homo sapiens
M12.222 Merops-ID Homo sapiens