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Literature summary for 3.4.24.B11 extracted from

  • Sandy, J.D.; Westling, J.; Kenagy, R.D.; Iruela-Arispe, M.L.; Verscharen, C.; Rodriguez-Mazaneque, J.C.; Zimmermann, D.R.; Lemire, J.M.; Fischer, J.W.; Wight, T.N.; Clowes, A.W.
    Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 (2001), J. Biol. Chem., 276, 13372-13378.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O cleavage site is Glu373-Ala374 Homo sapiens 2 aggrecan fragment
-
 ?
brevican + H2O clevage site is Glu395 Homo sapiens ?
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?
versican isoform V0 + H2O a second cleavage site might be Glu405-Gln406, cleavage site is Glu1428-Ala1429 in the V0 isoform, activity with recombinant and native human substrate protein Homo sapiens 2 peptides product identification ?
versican isoform V1 + H2O a second cleavage site might be Glu405-Gln406, cleavage site is Glu441-Ala442 in the V1 isoform, activity with recombinant and native human substrate protein Homo sapiens 2 peptides product identification ?

Synonyms

Synonyms Comment Organism
M12.222 Merops-ID Homo sapiens