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Literature summary for 3.4.24.87 extracted from
- Falsely low ADAMTS13 activity caused by levofloxacin (2019), Transfusion, 59, 2752-2753 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme cleaves a susceptible tyrosine-methionine bond located between amino acids 9 and 10 in a synthetic 77 amino acid substrate. Amino acid 3 is a glutamic acid residue to which the fluorescent 2-(N-methylamino)benzoyl group is covalently bonded. Amino acid 13 is a glycine residue to which the quenching agent 2,4 dinitrophenol is attached. Upon cleavage of the tyrosine-methionine bond, the quenching effect of the 2,4 dinitrophenol is reduced, and excitation of-(N-methylamino)benzoyl results in fluorescent emission measured at 440 nm | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS13 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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