Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | removal of the C-terminal domain of the enzyme by activated coagulation factor XI or alpha-thrombin causes an increase in enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q76LX8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 200000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
a thrombospondin type 1 motif, member 13 | - |
Homo sapiens |
ADAMTS13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | removal of the C-terminal domain of the enzyme by activated coagulation factor XI or alpha-thrombin blocks the ability of the enzyme to cleave von Willebrand factor on the endothelial cell surface, resulting in persistence of von Willebrand factor strands and causing an increase in platelet adhesion under flow conditions | Homo sapiens |