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Literature summary for 3.4.24.87 extracted from

  • Garland, K.S.; Reitsma, S.E.; Shirai, T.; Zilberman-Rudenko, J.; Tucker, E.I.; Gailani, D.; Gruber, A.; McCarty, O.J.T.; Puy, C.
    Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions (2017), Front. Med., 4, 232 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information removal of the C-terminal domain of the enzyme by activated coagulation factor XI or alpha-thrombin causes an increase in enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q76LX8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 200000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
a thrombospondin type 1 motif, member 13
-
Homo sapiens
ADAMTS13
-
Homo sapiens

General Information

General Information Comment Organism
physiological function removal of the C-terminal domain of the enzyme by activated coagulation factor XI or alpha-thrombin blocks the ability of the enzyme to cleave von Willebrand factor on the endothelial cell surface, resulting in persistence of von Willebrand factor strands and causing an increase in platelet adhesion under flow conditions Homo sapiens