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BRENDA support

Literature summary for 3.4.24.87 extracted from

  • Desch, K.C.; Kretz, C.; Yee, A.; Gildersleeve, R.; Metzger, K.; Agrawal, N.; Cheng, J.; Ginsburg, D.
    Probing ADAMTS13 substrate specificity using phage display (2015), PLoS ONE, 10, e0122931.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q76LX8
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
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Homo sapiens 2 peptides of 140 kDa and 176 kDa ADAMTS13 cleaves von Willebrand factor at the Y1605/M1606 peptide bond in the A2 domain. Mutant substrates L1603Q, L1603R, Y1605D, L1603R/Y1605N, Y1605N/M1606T, Y1605R/M1606T are resistant to cleavage. Mutant substrates R1597W, M1606T and I1616N are less efficiently cleaved than wild-type ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
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assay at Homo sapiens