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Literature summary for 3.4.24.87 extracted from

  • Hershko, K.; Simhadri, V.L.; Blaisdell, A.; Hunt, R.C.; Newell, J.; Tseng, S.C.; Hershko, A.Y.; Choi, J.W.; Sauna, Z.E.; Wu, A.; Bram, R.J.; Komar, A.A.; Kimchi-Sarfaty, C.
    Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat) (2012), J. Biol. Chem., 287, 44361-44371.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic purpura. Cyclosporin A, an inhibitor of cyclophilin B, reduces the secretion of ADAMTS13 and leads to conformational changes in the protein resulting in diminished ADAMTS13 proteolytic activity. Cyclophilin B and ADAMTS13 show a direct, functional interaction Homo sapiens
medicine ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic purpura. Cyclosporin A, an inhibitor of cyclophilin B, reduces the secretion of ADAMTS13 and leads to conformational changes in the protein resulting in diminished ADAMTS13 proteolytic activity. Cyclophilin B and ADAMTS13 show a direct, functional interaction Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens
expression in HEK-293 cell Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q76LX8
-
-
Mus musculus Q769J6
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-

Source Tissue

Source Tissue Comment Organism Textmining
liver
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Homo sapiens
-

General Information

General Information Comment Organism
metabolism cyclophilin B knock-out mice have reduced ADAMTS13 levels Mus musculus