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Literature summary for 3.4.24.87 extracted from

  • Zhang, J.; Ma, Z.; Dong, N.; Liu, F.; Su, J.; Zhao, Y.; Shen, F.; Wang, A.; Ruan, C.
    A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13 (2011), PLoS ONE, 6, e22157.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information coagulation factor VIII, platelet glycoprotein 1balpha, and heparin sulfate accelerate the cleavage of von Willebrand factor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information monoclonal antibody SZ34 inhibits proteolytic cleavage of VWF by ADAMTS13 in a concentration-dependent manner under fluid shear stress, but not under static/denaturing conditions (IC50 0.05 mg/ml). Thrombospondin-1 decreases the rate of von Willebrand factor proteolysis by ADAMTS13 by competing with ADAMTS13 for the A3 domain of von Willebrand factor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
Homo sapiens