Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | coagulation factor VIII, platelet glycoprotein 1balpha, and heparin sulfate accelerate the cleavage of von Willebrand factor | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | monoclonal antibody SZ34 inhibits proteolytic cleavage of VWF by ADAMTS13 in a concentration-dependent manner under fluid shear stress, but not under static/denaturing conditions (IC50 0.05 mg/ml). Thrombospondin-1 decreases the rate of von Willebrand factor proteolysis by ADAMTS13 by competing with ADAMTS13 for the A3 domain of von Willebrand factor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |