Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
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Synonyms | Comment | Organism |
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ADAMTS13 | - |
Homo sapiens |
General Information | Comment | Organism |
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additional information | antibody formation against ADAMTS13, as ADAMTS13 inhibitor, in the course of a severe acute Dengue virus infection results in thrombotic microangiopathy. Anti-ADAMTS13 inhibitor disappears after remission of thrombotic microangiopathy and dengue resolution. No recurrence of thrombotic microangiopathy symptoms after 2-year follow-up. Thrombotic microangiopathy is a severe occlusive microvascular thrombotic syndrome characterized by profound thrombocytopenia, microangiopathic hemolytic anemia, and symptoms of organ ischemia. Thrombotic microangiopathy includes primarily two syndromes, thrombotic thrombocytopenic purpura and hemolytic uremic syndrome | Homo sapiens |
physiological function | ADAMTS13 deficiency plays a central role in the pathogenesis of hereditary or acquired idiopathic thrombotic thrombocytopenic purpura | Homo sapiens |