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Literature summary for 3.4.24.87 extracted from

  • George, J.
    ADAMTS13: What it does, how it works, and why its important (2009), Transfusion, 49, 196-198.
    View publication on PubMed
Search for more literature for 3.4.24.87

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ADAMTS13 binds to CD36, a transmembrane protein of endothelial cells and platelets, i.e. glycoprotein IV, not diminishing the proteolytic activity of ADAMTS13, but providing an anchor for ADAMTS13 on the surface of endothelial cells and platelets ?
-
 ?
von Willebrand factor + H2O Homo sapiens specific cleavage of the long strings of ultra-large von Willebrand factor multimers von Willebrand factor fragments
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ADAMTS13 binds to CD36, a transmembrane protein of endothelial cells and platelets, i.e. glycoprotein IV, not diminishing the proteolytic activity of ADAMTS13, but providing an anchor for ADAMTS13 on the surface of endothelial cells and platelets Homo sapiens ?
-
 ?
von Willebrand factor + H2O specific cleavage of the long strings of ultra-large von Willebrand factor multimers Homo sapiens von Willebrand factor fragments
-
 ?
von Willebrand factor + H2O specific cleavage of the long strings of ultra-large von Willebrand factor multimers. The specificity of ADAMTS13 for proteolysis of von Willebrand factor is facilitated by multiple cooperative contacts that bind ADAMTS13 to von Willebrand factor Homo sapiens von Willebrand factor fragments
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
 Homo sapiens
More ADAMTS13 belongs to the family of a disintegrin-like and metalloprotease domains with repeated thrombospondin domains Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS-13 deficiency is the cause for thrombotic thrombocytopenic purpura, CD36 is involved, phenotype and clinical treatmemnts, detailed overview Homo sapiens