Application | Comment | Organism |
---|---|---|
diagnostics | ADAMTS-13 may serve as a diagnostic and prognostic marker of disseminated intravascular coagulation. Patients with a low activity of ADAMTS-13 have a poor survival rate compared to patients with a high activity of ADAMTS-13 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
intracellular | - |
Homo sapiens | 5622 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
additional information | ADAMTS-13 levels in healthy controls and patients with disseminated intravascular coagulation | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | ADAMTS-13 activity gradually decreases based on the disseminated intravascular coagulation score and D-dimer levels and is correlated with the antithrombin level, representing the consumption of ADAMTS-13 during the ongoing coagulation process. No correlation between ADAMTS-13 activity and neutrophil CD64 expression | Homo sapiens |