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Literature summary for 3.4.24.87 extracted from

  • Uemura, T.; Kaikita, K.; Yamabe, H.; Soejima, K.; Matsukawa, M.; Fuchigami, S.; Tanaka, Y.; Morihisa, K.; Enomoto, K.; Sumida, H.; Sugiyama, S.; Ogawa, H.
    Changes in plasma von Willebrand factor and ADAMTS13 levels associated with left atrial remodeling in atrial fibrillation (2009), Thromb. Res., 124, 28-32.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens specific cleavage of ultra-large von Willebrand factor multimers ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
paroxysmal and chronic atrial fibrillation patients and healthy controls
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma from paroxysmal and chronic atrial fibrillation patients and healthy controls, ADAMTS13 contents and activities, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O specific cleavage of ultra-large von Willebrand factor multimers Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS13 i.e. disintegrin-like domain and Metalloprotease with ThromboSpondin type I motif 13 Homo sapiens
vWF-cleaving protease
-
Homo sapiens

General Information

General Information Comment Organism
physiological function clinical relevance of ADAMTS13 activity is demonstrated by its reduction in thrombocytopenic purpura, metastasizing malignancies, liver disease, and the post-surgical state. Changes in plasma von Willebrand factor and ADAMTS13 levels are associated with left atrial remodeling in atrial fibrillation, phenotypes, overview Homo sapiens