Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | specific cleavage of ultra-large von Willebrand factor multimers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
paroxysmal and chronic atrial fibrillation patients and healthy controls | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | from paroxysmal and chronic atrial fibrillation patients and healthy controls, ADAMTS13 contents and activities, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | specific cleavage of ultra-large von Willebrand factor multimers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | i.e. disintegrin-like domain and Metalloprotease with ThromboSpondin type I motif 13 | Homo sapiens |
vWF-cleaving protease | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | clinical relevance of ADAMTS13 activity is demonstrated by its reduction in thrombocytopenic purpura, metastasizing malignancies, liver disease, and the post-surgical state. Changes in plasma von Willebrand factor and ADAMTS13 levels are associated with left atrial remodeling in atrial fibrillation, phenotypes, overview | Homo sapiens |