Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.87 extracted from

  • Trionfini, P.; Tomasoni, S.; Galbusera, M.; Motto, D.; Longaretti, L.; Corna, D.; Remuzzi, G.; Benigni, A.
    Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice (2009), Gene Ther., 16, 1373-1379.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information ability of systemically administered adenovirus encoding human ADAMTS13 to restore the deficient protein in the circulation of Adamts13-/- mice, derived from B/129 wild-type mice. Injection of the adenovirus efficiently transduces the liver, kidney, lung, heart and spleen, resulting in the secretion of ADAMTS13 into plasma, especially from lung and liver, not from brain, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA potent inhibitor of the metalloprotease ADAMTS13 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens cleavage of ultra-large multimers ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O cleavage of ultra-large multimers Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS13 is a plasma metalloprotease that regulates the size of the von Willebrand factor multimers. Genetic or acquired deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura, TTP Homo sapiens