Protein Variants | Comment | Organism |
---|---|---|
additional information | ability of systemically administered adenovirus encoding human ADAMTS13 to restore the deficient protein in the circulation of Adamts13-/- mice, derived from B/129 wild-type mice. Injection of the adenovirus efficiently transduces the liver, kidney, lung, heart and spleen, resulting in the secretion of ADAMTS13 into plasma, especially from lung and liver, not from brain, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | potent inhibitor of the metalloprotease ADAMTS13 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | cleavage of ultra-large multimers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | cleavage of ultra-large multimers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS13 is a plasma metalloprotease that regulates the size of the von Willebrand factor multimers. Genetic or acquired deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura, TTP | Homo sapiens |