Application | Comment | Organism |
---|---|---|
medicine | infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Thus, recombinant ADAMTS13 can be considered as a therapeutic agent for prevention and/or treatment of stroke. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzyme forms in HEK-293 cells and CHO cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Mus musculus | ADAMTS13 cleaves von Willebrand factor to smaller less-active forms | von Willebrand factor fragments | - |
? | |
von Willebrand factor + H2O | Homo sapiens | ADAMTS13 cleaves von Willebrand factor to smaller less-active forms | von Willebrand factor fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Mus musculus | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor to smaller less-active forms | Mus musculus | von Willebrand factor fragments | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves von Willebrand factor to smaller less-active forms | Homo sapiens | von Willebrand factor fragments | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 | Mus musculus |
ADAMTS13 | i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 | Homo sapiens |
von Willebrand factor-cleaving protease | - |
Mus musculus |
von Willebrand factor-cleaving protease | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model | Mus musculus |
additional information | infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model | Homo sapiens |
physiological function | ADAMTS13 negatively regulates both thrombosis and inflammation. ADAMTS13 deficiency results in larger infarctions after focal cerebral ischemia in mice, but only in mice that have von Willebrand factor | Mus musculus |
physiological function | ADAMTS13 negatively regulates both thrombosis and inflammation. ADAMTS13 deficiency results in larger infarctions after focal cerebral ischemia in mice, but only in mice that have von Willebrand factor | Homo sapiens |