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Literature summary for 3.4.24.87 extracted from

  • Zhao, B.Q.; Chauhan, A.K.; Canault, M.; Patten, I.S.; Yang, J.J.; Dockal, M.; Scheiflinger, F.; Wagner, D.D.
    von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke (2009), Blood, 114, 3329-3334.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Thus, recombinant ADAMTS13 can be considered as a therapeutic agent for prevention and/or treatment of stroke. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzyme forms in HEK-293 cells and CHO cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Mus musculus
-
-
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Mus musculus ADAMTS13 cleaves von Willebrand factor to smaller less-active forms von Willebrand factor fragments
-
?
von Willebrand factor + H2O Homo sapiens ADAMTS13 cleaves von Willebrand factor to smaller less-active forms von Willebrand factor fragments
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Mus musculus
-
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor to smaller less-active forms Mus musculus von Willebrand factor fragments
-
?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor to smaller less-active forms Homo sapiens von Willebrand factor fragments
-
?

Synonyms

Synonyms Comment Organism
ADAMTS13 i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 Mus musculus
ADAMTS13 i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 Homo sapiens
von Willebrand factor-cleaving protease
-
Mus musculus
von Willebrand factor-cleaving protease
-
Homo sapiens

General Information

General Information Comment Organism
additional information infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model Mus musculus
additional information infusion of a high dose of recombinant human ADAMTS13 into a wild-type mouse immediately before reperfusion reduces infarct volume and improves functional outcome without producing cerebral hemorrhage. Recombinant ADAMTS13 does not enhance bleeding in a hemorrhagic stroke model Homo sapiens
physiological function ADAMTS13 negatively regulates both thrombosis and inflammation. ADAMTS13 deficiency results in larger infarctions after focal cerebral ischemia in mice, but only in mice that have von Willebrand factor Mus musculus
physiological function ADAMTS13 negatively regulates both thrombosis and inflammation. ADAMTS13 deficiency results in larger infarctions after focal cerebral ischemia in mice, but only in mice that have von Willebrand factor Homo sapiens