Literature summary for 3.4.24.87 extracted from

Zhou, W.; Tsai, H.M.
N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity (2009), Blood, 113, 929-935.

Search for more literature for 3.4.24.87

Protein Variants

Protein Variants	Comment	Organism
N146Q	decreased secretion and von Willebrand factor cleaving activity	Homo sapiens
N552Q	decreased secretion	Homo sapiens
N828Q	decreased secretion and von Willebrand factor cleaving activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q76LX8	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	N-glycosylation is necessary for efficient secretion of ADAMTS13, while conversion of the N-glycans from oligomannose to complex type in the Golgi complex enhances the proteolytic activity of the protease toward von Willebrand factor multimers. After its secretion, ADAMTS13 does not require N-glycans for its von Willebrand factor cleaving activity	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)