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Literature summary for 3.4.24.87 extracted from
- Structural and functional correlation of ADAMTS13 (2007), Curr. Opin. Hematol., 14, 270-276.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ADAMTS13 deficiency and the resultant increase in von Willebrand factor adhesion activity may be clinically significant for association with the severity of thrombocytopenia and clinical prognosis in sepsis, sickle cell disease, and and increased risk for stroke | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| P475S | low activity | Homo sapiens |
| P618A/A732V | mutation induces secretion deficiency | Homo sapiens |
| Q448E | mutation has no significant effect on ADAMTS13 secretion | Homo sapiens |
| R1336 | mutation induces secretion deficiency | Homo sapiens |
| R7W | mutation has no significant effect on ADAMTS13 secretion | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | ADAMTS13 has a predicted calcium-binding site | Homo sapiens |  |
| Zn2+ | ADAMTS13 has a putative zinc catalytic site | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| blood plasma | - |
Homo sapiens | - |
| blood platelet | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| hepatic stellate cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS13 | - |
Homo sapiens |
| More | a disintegrin and metalloprotease with trombonspondin motif 13 | Homo sapiens |
| plasma von Willebrand factor cleaving activity | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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