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Literature summary for 3.4.24.87 extracted from
- Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo (2006), J. Thromb. Haemost., 4, 1063-1070.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CCl4 at concentration of 6.5 mM does not directly enhance the activity of ADAMTS-13 | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | complete inhibition at 10 mM | Rattus norvegicus |  |
| additional information | CCl4 at concentration of 6.5 mM does not directly inhibit the activity of ADAMTS-13 | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 195000 | - |
SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatic stellate cell | - |
Rattus norvegicus | - |
| hepatic stellate cell | the dramatically increased ADAMTS-13 protein and proteolytic activity in the activated hepatic stellate cells in vitro and in vivo may be important part of functions of activated hepatic stellate cells, perhaps by modulating the processes of liver regeneration or formation of liver fibrosis after various insults | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fluorescent resonance energy transfer-von Willebrand factor 73 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| von Willebrand factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease with thrombospondin-13 | - |
Rattus norvegicus |
| ADAMTS-13 | - |
Rattus norvegicus |
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