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Literature summary for 3.4.24.87 extracted from

  • Majerus, E.M.; Zheng, X.; Tuley, E.A.; Sadler, J.E.
    Cleavage of the ADAMTS13 propeptide is not required for protease activity (2003), J. Biol. Chem., 278, 46643-46648.
    View publication on PubMed
Search for more literature for 3.4.24.87

Activating Compound

Activating Compound Comment Organism Structure
Urea activates at 1 M Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression in HeLa cells, in HepG2 cells, in RFL6 cells, and in COS-1 cells, highest expression level is obtained in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
 peptides
-
 ?
von Willebrand factor + H2O Homo sapiens large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain 2 peptides of 140 kDa and 176 kDa
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein enzym contains 10 potential N-glycosylation sites Homo sapiens
proteolytic modification propeptide is very short and poorly conserved, dispensable for protein folding, is cleaved off by furin after export from the endoplasmic reticulum, the pro-enzyme form is fully active Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pro-von Willebrand factor is cleaved by pro-ADAMTS13 and by ADAMTS13 Homo sapiens ?
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?
von Willebrand factor + H2O cleavage of the peptide bond Tyr842-Met843 within the A2 domain Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
von Willebrand factor + H2O large multimeric substrate, cleavage of the peptide bond Tyr842-Met843 within the A2 domain Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS13 i.e. a disintegrin and metalloprotease with thrombospondin repeats Homo sapiens
M12.241 Merops-ID Homo sapiens
von-Willebrand factor cleaving protease
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 room temperature, assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens