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Literature summary for 3.4.24.87 extracted from

  • Dong, J.F.; Moake, J.L.; Nolasco, L.; Bernardo, A.; Arceneaux, W.; Shrimpton, C.N.; Schade, A.J.; McIntire, L.V.; Fujikawa, K.; Lopez, J.A.
    ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions (2002), Blood, 100, 4033-4039.
    View publication on PubMed
Search for more literature for 3.4.24.87

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activates Homo sapiens
guanidine activates Homo sapiens
Urea activates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
 peptides
-
 ?
von Willebrand factor + H2O Homo sapiens rapid physiological process that occurs on endothelial surfaces, activity is reduced by 87-100% in patients with thrombotic thrombocytopenic pupura 2 peptides of 176 kD and 140 kD
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proteins + H2O
-
 Homo sapiens peptides
-
 ?
von Willebrand factor + H2O large multimeric complexes are reduced to smaller ones, cleavage of peptide bond Tyr842-Met843 in the vWFdomain A2 Homo sapiens 2 peptides of 176 kD and 140 kD
-
 ?
von Willebrand factor + H2O rapid physiological process that occurs on endothelial surfaces, activity is reduced by 87-100% in patients with thrombotic thrombocytopenic pupura Homo sapiens 2 peptides of 176 kD and 140 kD
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS VWF cleaving metalloprotease
-
 Homo sapiens
ADAMTS13
-
 Homo sapiens
M12.241 Merops-ID Homo sapiens
VWF cleaving metalloprotease
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 9
-
 Homo sapiens