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Literature summary for 3.4.24.87 extracted from

  • Plaimauer, B.; Zimmermann, K.; Volkel, D.; Antoine, G.; Kerschbaumer, R.; Jenab, P.; Furlan, M.; Gerritsen, H.; Lammle, B.; Schwarz, H.P.; Scheiflinger, F.
    Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13) (2002), Blood, 100, 3626-3632.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression in HEK293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme is inhibited by plasma from an individuum with acquired thrombotic thrombocytopenic pupura Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activates, metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
peptides
-
?
von Willebrand factor + H2O Homo sapiens cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q76LX8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme expression Homo sapiens
-
heart enzyme expression Homo sapiens
-
kidney enzyme expression Homo sapiens
-
liver enzyme expression, adult and fetal Homo sapiens
-
muscle enzyme expression Homo sapiens
-
placenta enzyme expression Homo sapiens
-
plasma
-
Homo sapiens
-
testis enzyme expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proteins + H2O
-
Homo sapiens peptides
-
?
von Willebrand factor + H2O cleavage of peptide bond Tyr842-Met843, native and recombinant enzyme Homo sapiens ?
-
?
von Willebrand factor + H2O cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
Homo sapiens
M12.241 Merops-ID Homo sapiens
von Willebrand factor-cleaving protease
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens