Cloned (Comment) | Organism |
---|---|
transient expression in HEK293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme is inhibited by plasma from an individuum with acquired thrombotic thrombocytopenic pupura | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | plasma | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ba2+ | activates, metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
von Willebrand factor + H2O | Homo sapiens | cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q76LX8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | enzyme expression | Homo sapiens | - |
heart | enzyme expression | Homo sapiens | - |
kidney | enzyme expression | Homo sapiens | - |
liver | enzyme expression, adult and fetal | Homo sapiens | - |
muscle | enzyme expression | Homo sapiens | - |
placenta | enzyme expression | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
testis | enzyme expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
von Willebrand factor + H2O | cleavage of peptide bond Tyr842-Met843, native and recombinant enzyme | Homo sapiens | ? | - |
? | |
von Willebrand factor + H2O | cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |
M12.241 | Merops-ID | Homo sapiens |
von Willebrand factor-cleaving protease | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |