Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | - |
Homo sapiens | |
phorbol 12-myristate-13-acetate | PMA | Homo sapiens | |
phorbol ester | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
recombinantly expressed human TACE in plasmid transfected chinese hamster ovary cells | Homo sapiens |
General Stability | Organism |
---|---|
surface-biotinylated TACE is stable in Jurkat cells with a half-life of at least 8h | Homo sapiens |
TACE appears quite stable in untreated cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IC-3 | protects TACE from degradation by inhibiting either TACE itself or another metalloprotease | Homo sapiens | |
TIMP-3 | tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Homo sapiens | - |
HeLa cells | - |
Homo sapiens | - |
human monocytic cell line THP-1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein + H2O | alpha-secretase processing | Homo sapiens | ? | - |
? | |
L-selectin + H2O | regulates plasma membrane composition and releases soluble signaling molecules and receptors from cells | Homo sapiens | ? | - |
? | |
proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sheddase | - |
Homo sapiens |