Any feedback?
Literature summary for 3.4.24.85 extracted from
- Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs (1997), Mol. Cell, 1, 47-57.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO cell line | Cricetulus griseus |
| expressed in M19 cell line | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | M19 mutant cell line of CHO-K1 cells with no s2p activity | Cricetulus griseus |
| additional information | mutants in any of the histidines for phenylalanine or glutamic acid for alanine of the consensus metal-binding site abolished activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | O54862 | Chinese hamster, s2p cloned | - |
| Homo sapiens | O43462 | s2p cloned | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | cDNA library | Homo sapiens | - |
| ovary cell line | CHO-7 and M19 S2P deficient cell lines | Cricetulus griseus | - |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Zn | zinc metalloprotease | Homo sapiens |  |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
