Literature summary for 3.4.24.84 extracted from

Varela, I.; Cadinanos, J.; Pendas, A.M.; Gutierrez-Fernandez, A.; Folgueras, A.R.; Sanchez, L.M.; Zhou, Z.; Rodriguez, F.J.; Stewart, C.L.; Vega, J.A.; Tryggvason, K.; Freije, J.M.; Lopez-Otin, C.
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation (2005), Nature, 437, 564-568.

Search for more literature for 3.4.24.84

Application

Application	Comment	Organism
medicine	existence of a checkpoint response activated by the nuclear abnormalities caused by prelamin A accumulation, hyperactivation of the tumour suppressor p53 may cause accelerated ageing	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Zmste24-deficient mice, Zmpste24 deficiency elicits a stress signaling pathway that is evidenced by a marked upregulation of p53 target genes, accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-
heart	-	Mus musculus	-
kidney	-	Mus musculus	-
liver	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
FACE-1	-	Mus musculus
Zmpste24	-	Mus musculus

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Release 2023.1 (January 2023)