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Literature summary for 3.4.24.84 extracted from

  • Fujimura-Kamada, K.; Nouvet, F.J.; Michaelis, S.
    A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor (1997), J. Cell Biol., 136, 271-285.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
complementation of a ste24 mutant Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
E298A ability to complement the mating-defective phenotype of ste24-1 is lost Saccharomyces cerevisiae
E298D ability to complement the mating-defective phenotype of ste24-1 is lost Saccharomyces cerevisiae
H297A ability to complement the mating-defective phenotype of ste24-1 is lost Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
integral to membrane hydropathy analysis predicts multiple membrane spanning segments Saccharomyces cerevisiae
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information Zn-metalloprotease consensus motif HEXXH Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52300
-
x * 52300, deduced from nucleotide sequence Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a-factor + H2O Saccharomyces cerevisiae Ste24 is required for the first of the two N-terminal processing steps of mating pheromone a-factor fragments of a-factor
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a-factor + H2O mating pheromone a-factor Saccharomyces cerevisiae fragments of a-factor
-
?
a-factor + H2O Ste24 is required for the first of the two N-terminal processing steps of mating pheromone a-factor Saccharomyces cerevisiae fragments of a-factor
-
?

Subunits

Subunits Comment Organism
? x * 52300, deduced from nucleotide sequence Saccharomyces cerevisiae