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Literature summary for 3.4.24.83 extracted from

  • Bromberg-White, J.; Lee, C.S.; Duesbery, N.
    Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin (2010), Toxins, 2, 1038-1053.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
E687C inactive Bacillus anthracis
H686A inactive Bacillus anthracis
H690A inactive Bacillus anthracis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent metalloprotease Bacillus anthracis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
x * 90000, SDS-PAGE Bacillus anthracis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mitogen-activated protein kinase kinase 1 + H2O Bacillus anthracis
-
?
-
?
mitogen-activated protein kinase kinase 2 + H2O Bacillus anthracis
-
?
-
?
mitogen-activated protein kinase kinase 3 + H2O Bacillus anthracis
-
?
-
?
mitogen-activated protein kinase kinase 4 + H2O Bacillus anthracis
-
?
-
?
mitogen-activated protein kinase kinase 6 + H2O Bacillus anthracis
-
?
-
?
mitogen-activated protein kinase kinase 7 + H2O Bacillus anthracis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitogen-activated protein kinase kinase 1 + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase kinase 2 + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase kinase 3 + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase kinase 4 + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase kinase 6 + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase kinase 7 + H2O
-
Bacillus anthracis ?
-
?

Subunits

Subunits Comment Organism
? x * 90000, SDS-PAGE Bacillus anthracis

Synonyms

Synonyms Comment Organism
anthrax lethal factor
-
Bacillus anthracis
lethal toxin
-
Bacillus anthracis
LeTx
-
Bacillus anthracis

General Information

General Information Comment Organism
physiological function lethal toxin (LeTx) containing lethal factor is the major virulence factor contributing to anthrax. LeTx-mediated MAPKK inhibition alters endothelial cell function Bacillus anthracis