Protein Variants | Comment | Organism |
---|---|---|
E687C | inactive | Bacillus anthracis |
H686A | inactive | Bacillus anthracis |
H690A | inactive | Bacillus anthracis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc-dependent metalloprotease | Bacillus anthracis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
90000 | - |
x * 90000, SDS-PAGE | Bacillus anthracis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase kinase 1 + H2O | Bacillus anthracis | - |
? | - |
? | |
mitogen-activated protein kinase kinase 2 + H2O | Bacillus anthracis | - |
? | - |
? | |
mitogen-activated protein kinase kinase 3 + H2O | Bacillus anthracis | - |
? | - |
? | |
mitogen-activated protein kinase kinase 4 + H2O | Bacillus anthracis | - |
? | - |
? | |
mitogen-activated protein kinase kinase 6 + H2O | Bacillus anthracis | - |
? | - |
? | |
mitogen-activated protein kinase kinase 7 + H2O | Bacillus anthracis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase kinase 1 + H2O | - |
Bacillus anthracis | ? | - |
? | |
mitogen-activated protein kinase kinase 2 + H2O | - |
Bacillus anthracis | ? | - |
? | |
mitogen-activated protein kinase kinase 3 + H2O | - |
Bacillus anthracis | ? | - |
? | |
mitogen-activated protein kinase kinase 4 + H2O | - |
Bacillus anthracis | ? | - |
? | |
mitogen-activated protein kinase kinase 6 + H2O | - |
Bacillus anthracis | ? | - |
? | |
mitogen-activated protein kinase kinase 7 + H2O | - |
Bacillus anthracis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 90000, SDS-PAGE | Bacillus anthracis |
Synonyms | Comment | Organism |
---|---|---|
anthrax lethal factor | - |
Bacillus anthracis |
lethal toxin | - |
Bacillus anthracis |
LeTx | - |
Bacillus anthracis |
General Information | Comment | Organism |
---|---|---|
physiological function | lethal toxin (LeTx) containing lethal factor is the major virulence factor contributing to anthrax. LeTx-mediated MAPKK inhibition alters endothelial cell function | Bacillus anthracis |