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Literature summary for 3.4.24.83 extracted from
- Binding and cell intoxication studies of anthrax lethal toxin (2012), Mol. Biol. Rep., 2012, 1-7.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | blood borne lethal toxin is a novel therapeutic target for combating anthrax | Bacillus anthracis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Bacillus anthracis |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 91000 | - |
x * 91000, lethal factor, SDS-PAGE | Bacillus anthracis |
| 710000 | - |
x * 710000, lethal toxin, SDS-PAGE | Bacillus anthracis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase + H2O | Bacillus anthracis | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Superose 6 gel filtration | Bacillus anthracis |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, purified lethal toxin, at least 3 months, no loss of activity | Bacillus anthracis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase + H2O | - |
Bacillus anthracis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 710000, lethal toxin, SDS-PAGE | Bacillus anthracis |
| ? | x * 91000, lethal factor, SDS-PAGE | Bacillus anthracis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lethal factor | - |
Bacillus anthracis |
| lethal toxin | - |
Bacillus anthracis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the Lethal Toxin is formed when up to three molecules of lethal factor bind a 63 kDA protective antigen heptamer. Anthrax lethal toxin is a major virulence factor of Bacillus anthracis. Fully assembled lethal toxin binds an anthrax toxin receptor with almost 100fold higher affinity than the protective antigen alone | Bacillus anthracis |
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Release 2023.1 (January 2023)
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