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Literature summary for 3.4.24.83 extracted from

  • Liu, T.; Milia, E.; Warburton, R.R.; Hill, N.S.; Gaestel, M.; Kayyali, U.S.
    Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling (2012), J. Cell. Physiol., 227, 1438-1445.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MAP kinase kinase 3b + H2O Bacillus anthracis
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MAP kinase kinase 3b + H2O
-
 Bacillus anthracis ?
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 ?

Synonyms

Synonyms Comment Organism
anthrax lethal factor
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 Bacillus anthracis
LeTx lethal toxin is composed of lethal factor and the protective antigen Bacillus anthracis

General Information

General Information Comment Organism
physiological function treatment of rat pulmonary microvascular endothelial cells with anthrax lethal toxin (LeTx) increases endothelial barrier permeability and gap formation between endothelial cells through disrupting p38 signaling. LeTxr educes phosphorylation of p38, MAP kinase 2, and HSP27 Bacillus anthracis