Literature summary for 3.4.24.83 extracted from

Ha, S.D.; Ham, B.; Mogridge, J.; Saftig, P.; Lin, S.; Kim, S.O.
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm (2010), J. Biol. Chem., 285, 2120-2129.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

General Information

General Information	Comment	Organism
physiological function	the cytoplasmic delivery of anthrax lethal factor by anthrax toxin receptor ANTXR2 is mediated by cathepsin B and requires lysosomal fusion with anthrax lethal toxin containing endosomes. Binding of protective antigen to ANXTR1 or -2 triggers autophagy, which facilitates the cytoplasmic delivery of ANTXR2-associated anthrax lethal factor. Whereas cells treated with the membrane-permeable cathepsin B inhibitor CA074-Me- orcathepsin B-deficient cells have no defect in fusion of light chain 3-containing autophagic vacuoles with lysosomes, autophagic flux is significantly delayed	Bacillus anthracis

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Release 2023.1 (January 2023)