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Literature summary for 3.4.24.83 extracted from
- Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses (2007), Int. J. Biochem. Cell Biol., 39, 20-24.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | lethal factor along with its receptor-binding partner protective antigen, forms lethal toxin, a critical virulence factor for bacillus anthracis. Lethal factor is a Zn2+ protease | Bacillus anthracis |  |
| Zn2+ | Zn2+ protease | Bacillus anthracis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bacillus anthracis | lethal factor acts directly on T and B lymphocytes, blocking antigen receptor-dependent proliferation, cytokine production and Ig production. In this manner, lethal factor mounts a broad-based attack on host-immunity, thus providing Bacillus anthracis with multiple mechanisms for avoiding protective host responses | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase + H2O | - |
Bacillus anthracis | ? | - |
? | |
| additional information | lethal factor acts directly on T and B lymphocytes, blocking antigen receptor-dependent proliferation, cytokine production and Ig production. In this manner, lethal factor mounts a broad-based attack on host-immunity, thus providing Bacillus anthracis with multiple mechanisms for avoiding protective host responses | Bacillus anthracis | ? | - |
? | |
| additional information | does not cleave MEK5 | Bacillus anthracis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| anthrax lethal factor | anthrax lethal factor along with its receptor-binding partner protective antigen forms anthrax lethal toxin | Bacillus anthracis |
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