Literature summary for 3.4.24.81 extracted from

Riethmueller, S.; Ehlers, J.C.; Lokau, J.; Duesterhoeft, S.; Knittler, K.; Dombrowsky, G.; Groetzinger, J.; Rabe, B.; Rose-John, S.; Garbers, C.
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17 (2016), Sci. Rep., 6, 25550 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
GI254023X	-	Homo sapiens
GW280264X	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	activation of the enzyme can be achieved by cellular influx of Ca2+	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
interleukin-6 receptor + H2O	Homo sapiens	-	sIL-6R fragment + C-terminal fragment	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14672	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
interleukin-6 receptor + H2O	-	Homo sapiens	sIL-6R fragment + C-terminal fragment	-	?

Synonyms

Synonyms	Comment	Organism
ADAM10	-	Homo sapiens

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Release 2023.1 (January 2023)