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Literature summary for 3.4.24.81 extracted from

  • Endres, K.; Deller, T.
    Regulation of alpha-secretase ADAM10 in vitro and in vivo Genetic, epigenetic, and protein-based mechanisms (2017), Front. Mol. Neurosci., 10, 56 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Activating Compound

Activating Compound Comment Organism Structure
tetraspanin 10
-
 Homo sapiens
tetraspanin 12
-
 Homo sapiens
tetraspanin 14
-
 Homo sapiens
tetraspanin 15
-
 Homo sapiens
tetraspanin 17
-
 Homo sapiens
tetraspanin 33
-
 Homo sapiens
tetraspanin 5
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
Golgi apparatus
-
 Homo sapiens 5794
-
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alcadein + H2O Homo sapiens
-
 ?
-
 ?
annexin A1 + H2O Homo sapiens
-
 ?
-
 ?
beta-amyloid precursor protein + H2O Homo sapiens
-
 sAPP-alpha fragment + C-terminal fragment
-
 ?
Bri2 + H2O Homo sapiens
-
 ?
-
 ?
C4.4A + H2O Homo sapiens
-
 ?
-
 ?
Cad6B + H2O Homo sapiens
-
 ?
-
 ?
CD154 + H2O Homo sapiens
-
 ?
-
 ?
cell adhesion molecule 1 + H2O Homo sapiens
-
 ?
-
 ?
collagen type XVII + H2O Homo sapiens
-
 ?
-
 ?
coxsackievirus and adenovirus receptor + H2O Homo sapiens
-
 ?
-
 ?
FAT1 + H2O Homo sapiens
-
 ?
-
 ?
gp130 + H2O Homo sapiens
-
 ?
-
 ?
interleukin 11R + H2O Homo sapiens
-
 ?
-
 ?
Klotho + H2O Homo sapiens
-
 ?
-
 ?
L1 adhesion molecule + H2O Homo sapiens
-
 ?
-
 ?
Leda-1 + H2O Homo sapiens
-
 ?
-
 ?
N-cadherin + H2O Homo sapiens
-
 ?
-
 ?
nerveglia antigen 2 + H2O Homo sapiens
-
 ?
-
 ?
neuroligin 1 + H2O Homo sapiens
-
 ?
-
 ?
Notch-1 + H2O Homo sapiens
-
 ?
-
 ?
PMEL17 + H2O Homo sapiens
-
 ?
-
 ?
SIRPalpha + H2O Homo sapiens
-
 ?
-
 ?
TACI + H2O Homo sapiens
-
 ?
-
 ?
TREM2 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the enzyme has four potential N-glycosylation sites (N267, N278, N439 and N551) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alcadein + H2O
-
 Homo sapiens ?
-
 ?
annexin A1 + H2O
-
 Homo sapiens ?
-
 ?
beta-amyloid precursor protein + H2O
-
 Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?
Bri2 + H2O
-
 Homo sapiens ?
-
 ?
C4.4A + H2O
-
 Homo sapiens ?
-
 ?
Cad6B + H2O
-
 Homo sapiens ?
-
 ?
CD154 + H2O
-
 Homo sapiens ?
-
 ?
cell adhesion molecule 1 + H2O
-
 Homo sapiens ?
-
 ?
collagen type XVII + H2O
-
 Homo sapiens ?
-
 ?
coxsackievirus and adenovirus receptor + H2O
-
 Homo sapiens ?
-
 ?
FAT1 + H2O
-
 Homo sapiens ?
-
 ?
gp130 + H2O
-
 Homo sapiens ?
-
 ?
interleukin 11R + H2O
-
 Homo sapiens ?
-
 ?
Klotho + H2O
-
 Homo sapiens ?
-
 ?
L1 adhesion molecule + H2O
-
 Homo sapiens ?
-
 ?
Leda-1 + H2O
-
 Homo sapiens ?
-
 ?
N-cadherin + H2O
-
 Homo sapiens ?
-
 ?
nerveglia antigen 2 + H2O
-
 Homo sapiens ?
-
 ?
neuroligin 1 + H2O
-
 Homo sapiens ?
-
 ?
Notch-1 + H2O
-
 Homo sapiens ?
-
 ?
PMEL17 + H2O
-
 Homo sapiens ?
-
 ?
SIRPalpha + H2O
-
 Homo sapiens ?
-
 ?
TACI + H2O
-
 Homo sapiens ?
-
 ?
TREM2 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
 Homo sapiens
ADAM10
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated at injury sites and in denervated areas of the brain following brain injury up

General Information

General Information Comment Organism
physiological function the enzyme has deleterious effects for patients with brain tumors because it may promote the spreading of tumor cells. The level and/or activity of ADAM10 affects neuronal structures in the adult brain, in particular dendritic spines Homo sapiens