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Literature summary for 3.4.24.81 extracted from

  • Altmeppen, H.C.; Prox, J.; Krasemann, S.; Puig, B.; Kruszewski, K.; Dohler, F.; Bernreuther, C.; Hoxha, A.; Linsenmeier, L.; Sikorska, B.; Liberski, P.P.; Bartsch, U.; Saftig, P.; Glatzel, M.
    The sheddase ADAM10 is a potent modulator of prion disease (2015), eLife, 4, e04260 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme can cut normal prion proteins from the surface of neurons ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O35598
-
-

Source Tissue

Source Tissue Comment Organism Textmining
forebrain
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme can cut normal prion proteins from the surface of neurons Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ADAM10
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme depletion in forebrain neurons leads to posttranslational increase of cellular prion protein levels Mus musculus
physiological function the enzyme is a potent modulator of prion disease Mus musculus