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Literature summary for 3.4.24.81 extracted from

  • Vincent, B.
    Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels (2016), Brain Res. Bull., 126, 154-169 .
    View publication on PubMed
Search for more literature for 3.4.24.81

Activating Compound

Activating Compound Comment Organism Structure
5-hydroxytryptamine receptor
-
 Homo sapiens
acetyl-L-carnitine
-
 Homo sapiens
ADAM15
-
 Homo sapiens
ADAM9
-
 Homo sapiens
bombesin receptor
-
 Homo sapiens
cryptotanshinone
-
 Homo sapiens
Deprenyl
-
 Homo sapiens
donezipil
-
 Homo sapiens
epigallocatechin-3-gallate
-
 Homo sapiens
FLZ synthetic analogue of natural squamosamide Homo sapiens
formononentin
-
 Homo sapiens
furin
-
 Homo sapiens
G-protein-coupled purinergic receptor
-
 Homo sapiens
gintonin
-
 Homo sapiens
glucagon-like peptide-1 receptor
-
 Homo sapiens
ion channel purinergic receptor
-
 Homo sapiens
metallothionein III
-
 Homo sapiens
nardilysin
-
 Homo sapiens
pituitary adenylate cyclase-activating polypeptide receptor
-
 Homo sapiens
synapse-associated protein 97
-
 Homo sapiens
tetraspanin 12
-
 Homo sapiens
tetraspanin 27
-
 Homo sapiens
tetraspanin 28
-
 Homo sapiens
tetraspanin 29
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q170H the mutation in the pro-domain region of the ADAM10 gene reduce alpha-secretase activity of the enzyme Homo sapiens
R181G the mutation in the pro-domain region of the ADAM10 gene reduce alpha-secretase activity of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GI254023X specific inhibitor Homo sapiens
nerve growth factor
-
 Homo sapiens
Rapamycin
-
 Homo sapiens
RECK
-
 Homo sapiens
Sfrp
-
 Homo sapiens
TIMP-1
-
 Homo sapiens
TIMP-3
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein + H2O Homo sapiens cleavage at Lys683-Leu684 sAPP-alpha fragment + C-terminal fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
hippocampus
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O cleavage at Lys683-Leu684 Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
 Homo sapiens
AD10
-
 Homo sapiens
ADAM10
-
 Homo sapiens
CD156c
-
 Homo sapiens
HsT18717
-
 Homo sapiens
kuz
-
 Homo sapiens
MADM
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000001
-
 TIMP-1 pH and temperature not specified in the publication Homo sapiens
0.0000009
-
 TIMP-3 pH and temperature not specified in the publication Homo sapiens
0.000005
-
 GI254023X pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is directly involved in the development of Alzheimer's disease, prion diseases, fragile X syndrome and possibly Huntington disease Homo sapiens