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Literature summary for 3.4.24.81 extracted from

  • Dempsey, P.J.
    Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis (2017), Biochim. Biophys. Acta Mol. Cell Res., 1864, 2228-2239 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Mus musculus
-
 ?
-
 ?
Notch S2 + H2O Mus musculus the enzyme is responsible for proteolytic cleavage at the S2 cleavage site within the extracellular juxtamembrane region of the Notch C-terminal fragment, which leads to the removal of the Notch ectodomain and the generation of a membrane-anchored Notch C-terminal fragment, termed Notch extracellular truncation Notch extracellular truncation fragment + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-
enteric neuron
-
 Mus musculus
-
epithelial cell
-
 Mus musculus
-
intestine
-
 Mus musculus
-
intestine in the adult intestine, ADAM10 is abundantly expressed on the basolateral cell surface of all intestinal epithelial cells Mus musculus
-
lamina propria
-
 Mus musculus
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leukocyte
-
 Mus musculus
-
pericryptal myofibroblast
-
 Mus musculus
-
smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O
-
 Mus musculus ?
-
 ?
Notch S2 + H2O the enzyme is responsible for proteolytic cleavage at the S2 cleavage site within the extracellular juxtamembrane region of the Notch C-terminal fragment, which leads to the removal of the Notch ectodomain and the generation of a membrane-anchored Notch C-terminal fragment, termed Notch extracellular truncation Mus musculus Notch extracellular truncation fragment + ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM10
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient embryos die at E 9.5 due to developmental defects in somitogenesis, neurogenesis and vasculogenesis Mus musculus
physiological function the enzyme is essential for intestinal development. Several signaling pathways that undergo ectodomain shedding by the enzyme (e.g. Notch, EGFR/ErbB, interleukin-6/sinterleukin-6R) help control intestinal injury/regenerative responses and may drive intestinal inflammation and colon cancer initiation and progression. The enzyme is associated with regulated intramembrane proteolysis activity Mus musculus