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Literature summary for 3.4.24.81 extracted from

  • von Hoven, G.; Rivas, A.J.; Neukirch, C.; Klein, S.; Hamm, C.; Qin, Q.; Meyenburg, M.; Fueser, S.; Saftig, P.; Hellmann, N.; Postina, R.; Husmann, M.
    Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus alpha-toxin action (2016), Biochem. J., 473, 1929-1940 .
    View publication on PubMed
Search for more literature for 3.4.24.81

Inhibitors

Inhibitors Comment Organism Structure
GI254023X selective inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Homo sapiens efficient cleavage of the ADAM10 substrate epithelial cadherin (E-cadherin) requires supra-cytotoxic concentrations of alpha-toxin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O efficient cleavage of the ADAM10 substrate epithelial cadherin (E-cadherin) requires supra-cytotoxic concentrations of alpha-toxin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 10
-
 Homo sapiens
ADAM10
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme critically contributes to alpha-toxin-dependent pathology of experimental Staphylococcus aureus infections in mice Homo sapiens
physiological function the enzyme promotes binding of alpha-toxin to human keratinocytes. The enzyme is required but insufficient to sensitize cells to alpha-toxin. The enzyme does not sensitize cells to Vibrio cholerae cytolysin Homo sapiens