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Literature summary for 3.4.24.81 extracted from

  • Nagara, Y.; Hagiyama, M.; Hatano, N.; Futai, E.; Suo, S.; Takaoka, Y.; Murakami, Y.; Ito, A.; Ishiura, S.
    Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex (2012), Biochem. Biophys. Res. Commun., 417, 462-467.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cell adhesion molecule CADM1 + H2O type I transmembrane glycoprotein, endopeptidase ADAM10 mediates endogenous CADM1 shedding. The membrane-bound fragment generated by shedding is further cleaved by gammaetase and generates CADM1-intracellular domain Homo sapiens ?
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