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Literature summary for 3.4.24.81 extracted from
- Regulation of alpha-secretase ADAM10 expression and activity (2011), Exp. Brain Res., 2011, 1-10.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | upregulation of ADAM10 is a therapeutic target in Alzheimers disease | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S441A | the mutant displays higher susceptibility to proteolysis | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vesicle | exosomal | Homo sapiens | 31982 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | ADAm10 possesses four potential N-glycosylation sites | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloproteinase 10 | - |
Homo sapiens |
| ADAM10 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | ADAM10 mRNA is lowered in moderate to severe Alzheimers disease | down |
| Homo sapiens | amount and activity of ADAM10 is increased by application of low doses of statins | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAM10 is the major alpha-secretase in vivo | Homo sapiens |
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Release 2023.1 (January 2023)
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