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Literature summary for 3.4.24.81 extracted from

  • Bozkulak, E.C.; Weinmaster, G.
    Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling (2009), Mol. Cell. Biol., 29, 5679-5695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch1 + H2O Mus musculus although Notch1 is a substrate for both ADAM10 and ADAM17, the particular ADAM required for receptor activation is context dependent. Specifically, ADAM10 is absolutely required for Notch1 signaling induced by ligands. Noth proteases participated in signaling intrinsic to Notch1 mutations associated with leukemia ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch1 + H2O
-
 Mus musculus ?
-
 ?
Notch1 + H2O although Notch1 is a substrate for both ADAM10 and ADAM17, the particular ADAM required for receptor activation is context dependent. Specifically, ADAM10 is absolutely required for Notch1 signaling induced by ligands. Noth proteases participated in signaling intrinsic to Notch1 mutations associated with leukemia Mus musculus ?
-
 ?

General Information

General Information Comment Organism
physiological function although Notch1 is a substrate for both ADAM10 and ADAM17, the particular ADAM required for receptor activation is context dependent. Specifically, ADAM10 is absolutely required for Notch1 signaling induced by ligands. Noth proteases participated in signaling intrinsic to Notch1 mutations associated with leukemia Mus musculus