Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.81 extracted from

  • Xu, D.; Sharma, C.; Hemler, M.E.
    Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein (2009), FASEB J., 23, 3674-3681.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ADAM10 plays a critical role in Alzheimer’s disease. Tetraspanin12 serves as a robust partner for ADAM10 and promotes ADAM10 maturation, thereby facilitating ADAM10-dependent proteolysis of amyloid precursor protein. This mode of regulating amyloid precursor protein cleavage is of relevance to Alzheimer’s disease therapy. Promotion of TSPAN12-ADAM10-dependent functions should be therapeutically beneficial in Alzheimer’s disease, whereas inhibition of TSPAN12-ADAM functions may be beneficial in cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens tetraspanin12 associates with mature ADAM10, promotes ADAM10 maturation, and enhances ADAM10 dependent cleavage of amyloid precursor protein ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification tetraspanin overexpression enhances ADAM10 prodomain maturation, whereas TSPAN12 ablation diminishes ADAM10 maturation. TSPAN12 serves as a robust partner for ADAM10 and promotes ADAM10 maturation, thereby facilitating ADAM10-dependent proteolysis of amyloid precursor protein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell confirmation of ADAM10-TSPAN12 association Homo sapiens
-
MDA-MB-231 cell confirmation of ADAM10-TSPAN12 association Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
Homo sapiens ?
-
?
amyloid precursor protein + H2O tetraspanin12 associates with mature ADAM10, promotes ADAM10 maturation, and enhances ADAM10 dependent cleavage of amyloid precursor protein Homo sapiens ?
-
?