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Literature summary for 3.4.24.81 extracted from
- The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1 (2009), FEBS J., 276, 1568-1580.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | in vivo investigations of mice overexpressing either ADAM10 or dominant negative ADAM10 show unaltered cleavage of neuregulin-1 compared to wild-type animals. As a consequence, the myelin sheath thickness of peripheral nerves is unaffected in mice with altered ADAM10 activity | Mus musculus |
| additional information | RNA interference (RNAi)-induced knockdown of ADAM10 in human astroglioma cell line U373 has no influence on NRG-1 (neuregulin-1) shedding | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| U-373MG cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | - |
Mus musculus |
| ADAM10 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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