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Literature summary for 3.4.24.81 extracted from
- Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b (2008), J. Biol. Chem., 283, 1644-1652.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GI254023 | 0.005 mM | Homo sapiens |  |
| GW280264 | 0.005 mM | Homo sapiens | |
| TAPI-1 | 0.05 mM | Homo sapiens | |
| TAPI-2 | 0.05 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Homo sapiens | sAPP-alpha fragment + C-terminal fragment | - |
? | |
| Bri2 protein + H2O | - |
Homo sapiens | ? | the ADAM10 cleavage liberates the BRICHOS domain of Bri2 | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloproteinase 10 | - |
Homo sapiens |
| ADAM10 | - |
Homo sapiens |
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