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Literature summary for 3.4.24.81 extracted from
- Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17 (2008), Curr. Alzheimer Res., 5, 187-201.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | Kuzbanian, the ADAM10 orthologue in Drosophila melanogaster plays an important role in axon guidance by building a complex with ephrinA2, which is cleaved off from the membrane in a moment of EphA3 receptor binding | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | in ADAM10 deficient mouse embryonic cells the constitutive release of soluble epidermal growth factor and also beta-cellulin is strongly reduced when compared with wild type controls and can be reintroduced by adding of wild type ADAM10. Overexpression of ADAM10 causes an increase in beta-cellulin shedding, whereas the overexpression of catalytically inactive ADAM10 decreases the beta-cellulin shedding | Mus musculus |
| additional information | the ADAM10 knockout mouse virtually represents a phenocopy of a presenilin 1/presenilin 2 double deficient mouse and thus features many traits attributable to defective Notch signalling | Mus musculus |
| additional information | the in vivo relevance of the processing of E-cadherin is supported by data from cell extracts from ADAM10 deficient mouse embryos at embryonic day 9.5, indicating that the generation is completely abolished in the knockout mice | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
in Drosophila, the ADAM10 orthologue kuzbanian acts act as Notch sheddase | - |
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kuzbanian | - |
Drosophila melanogaster |
| kuzbanian | - |
Mus musculus |
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