Literature summary for 3.4.24.81 extracted from

Sanderson, M.P.; Erickson, S.N.; Gough, P.J.; Garton, K.J.; Wille, P.T.; Raines, E.W.; Dunbar, A.J.; Dempsey, P.J.
ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx (2005), J. Biol. Chem., 280, 1826-1837.

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Activating Compound

Activating Compound	Comment	Organism	Structure
(4-aminophenyl)mercuric acetate	-	Mus musculus
A23187	calcium ionophore	Mus musculus
additional information	no activation by 0.1 M phorbol 12-myristate 13-acetate	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-isobutylsuccinamide	GM6001, 0.05 mM	Mus musculus
rottlerin	protein kinase Cdelta inhibitor causes a dramatic decrease in the activation of pro-BTC shedding by calcium ionophore A23187	Mus musculus
tissue inhibitor of metalloproteases 1	500 nM TIMP-1	Mus musculus
tissue inhibitor of metalloproteases 3	500 nM TIMP-3	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-
stomach	stomach epithelial cell	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
betacellulin precursor + H2O	-	Mus musculus	additional information	one major (26-28 kDa) soluble form + two minor (20 and 15 kDa) soluble forms + cellular remnant lacking the ectodomain (12 kDa)	?

Synonyms

Synonyms	Comment	Organism
ADAM10	-	Mus musculus

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Release 2023.1 (January 2023)