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Literature summary for 3.4.24.81 extracted from

  • McCulloch, D.R.; Akl, P.; Samaratunga, H.; Herington, A.C.; Odorico, D.M.
    Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP (2004), Clin. Cancer Res., 10, 314-323.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5alpha-dihydrotestosterone 10 nM, in the presence of 10 or 50 ng/ml insulin-like growth factor, 1.8fold upregulation of the 100-kDa proform and 3 to 4 fold stimulation of the active 60-kDa form Homo sapiens
Epidermal growth factor 50 ng/ml, 2fold stimulation of 100-kDa proform and 3fold stimulation of 60-kDa form Homo sapiens
insulin-like growth factor I 10 ng/ml or 50 ng/ml, in the presence of 10 nM 5alpha-dihydrotestosterone, 1.8fold upregulation of the 100-kDa proform and 3 to 4fold stimulation of the active 60-kDa form Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
SDS-PAGE, active form of ADAM-10 Homo sapiens
100000
-
SDS-PAGE, proform of ADAM-10 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell line cell line LNCaP, localized to the secretory cells of prostate glands, with additional basal cell expression in benign glands Homo sapiens
-

Synonyms

Synonyms Comment Organism
ADAM-10 disintegrin metalloprotease Homo sapiens