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Literature summary for 3.4.24.81 extracted from

  • Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
    Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase (2003), Biochem. Biophys. Res. Commun., 301, 231-235.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein Homo sapiens A172 cell line has alpha-secretase activity sAPP-alpha fragment + C-terminal fragment
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 cell line
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Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell A-172 cell line has potent alpha-secretase activity, higher than HEK-293 cell line Homo sapiens
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bone marrow there is expression of the enzyme Homo sapiens
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brain there is expression of the enzyme Homo sapiens
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kidney cell line there is expression of the enzyme Homo sapiens
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liver there is expression of the enzyme Homo sapiens
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lymph node there is expression of the enzyme Homo sapiens
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spleen there is expression of the enzyme Homo sapiens
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thymus there is expression of the enzyme Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein A172 cell line has alpha-secretase activity Homo sapiens sAPP-alpha fragment + C-terminal fragment
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 ?